SISTER CHROMATID EXCHANGES IN PHOTOCHEMOTHERAPY

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Sister chromatid exchanges in lymphocytes of humans anaesthetized with isoflurane.

The potential mutagenicity of isoflurane was investigated by the sister chromatid exchange (SCE) test using peripheral blood lymphocytes from patients before and after anaesthesia. Thirty patients, aged 18-59 yr (median 29.5 yr), were anaesthetized for minor orthopaedic operations with isoflurane and nitrous oxide in oxygen for 37-90 min (median 64 min). Venous blood samples were drawn before t...

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Analysis of sister-chromatid exchanges and tumorigenicity in cell hybrids.

The relationship between the 'spontaneous' frequency of sister-chromatid exchanges (SCE) and tumorigenicity was studied in a series of hybrids between a C57BL melanoma cell line and diploid cells, but no correlation was found between the 2 variables. Hybrids in which malignancy was suppressed and malignant segregants derived from them showed virtually identical SCE frequencies. Variation of SCE...

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Induction of sister chromatid exchanges in human lymphocytes by DTPA.

The chelating agent, diethylenetriaminepentaacetic acid (DTPA) is a non-registered drug used in the treatment of over-exposure to heavy metals such as iron, zinc and lead (Fahey et al., 1961; Brugsch et al., 1965). DTPA has also been used on a few occasions in the United Kingdom when individuals have inhaled plutonium dust or received contaminated wounds (Schofield and Dolphin, 1974). These pat...

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Sister chromatid exchanges in human lymphocytes after anaesthesia with fluroxene.

The potential mutagenicity of fluroxene was investigated by the sister chromatid exchange (SCE) test using lymphocytes in peripheral blood from patients before and after anaesthesia. Twenty-five female patients, aged 21 -77 yr (median 36.5yr) were anaesthetized for gynaecological operations with fluroxene in nitrous oxide for 60-220 nun (median 110 min). The number of SCE per cell was the same ...

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Sister chromatid exchanges in human lymphocytes treated with silica.

The abilities of Min U Sil quartz or tridymite particles to induce sister chromatid exchanges (SCEs) in cultures of human lymphocytes plus monocytes or of human purified lymphocytes were investigated. With cultures of lymphocytes plus monocytes the level of SCEs was significantly enhanced after treatment with tridymite at the highest dose tested (50 micrograms/cm2). No effect was observed with ...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 1977

ISSN: 0022-202X

DOI: 10.1111/1523-1747.ep12510317